5/1/2025
Last update
5/1/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.5
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Advanced 40+ Acidophilus 1.5 billion CFUproviding:Lactobacillus. acidophilus, (LA-5®)300 million CFULactobacillus rhamnosus GG (LGG®)300 million CFULactobacillus paracasei (L. CASEI 431®)300 million CFU Bifidobacterium lactis (BB-12®)300 million CFUStreptococcus thermophilus, (TH-4®)300 million CFU
2.4 mg
**
Top Medical Research Studies
9
Lacticaseibacillus rhamnosus shows promise
We explored the potential of Lacticaseibacillus rhamnosus GG as a probiotic treatment against avian pathogenic E. coli (APEC) in chickens. Our study showed that this probiotic significantly reduced APEC colonization in the chickens' cecum and improved the balance of gut microbiota over a 24-hour period.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
Read More
9
We aimed to find out if probiotic supplements like lactobacillus acidophilus could help counteract the negative effects of iron fortification, which has been linked to increased diarrhea and food poisoning among children.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
Read More
9
We investigated how a specific strain of Lactococcus lactis can help prevent food poisoning caused by a common pathogen found in raw milk and cheese. Our results showed a significant decrease in pathogen levels—by around 3 log CFU/mL—within just six hours when this strain was present.
Even more promising, it reduced the production of staphylococcal enterotoxin A (SEA) by 79%. In cheeses made with Lactococcus lactis, SEA was never detected, while it was found in higher levels in cheeses made without this protective strain. This study clearly shows Lactococcus lactis's potential in enhancing food safety through biopreservation.
Even more promising, it reduced the production of staphylococcal enterotoxin A (SEA) by 79%. In cheeses made with Lactococcus lactis, SEA was never detected, while it was found in higher levels in cheeses made without this protective strain. This study clearly shows Lactococcus lactis's potential in enhancing food safety through biopreservation.
Read More
Most Useful Reviews
9
Convenient probiotic
8 people found this helpful
Working probiotic! A convenient product with positive results after two months. It has helped my whole family cope during these challenging times when food quality is often poor. I am ordering more and recommend it to friends!
Read More
7
Restores microflora
5 people found this helpful
Works well and restores intestinal microflora effectively. I take it in the morning on an empty stomach or at night with water. It aids digestion and is necessary for inflammation of the pancreas. A very good drug that I recommend.
Read More
7.5
Effective for intestines
1 people found this helpful
An effective product! These probiotics perfectly help with my intestines, which struggle to function properly. I previously took six capsules of Lineks daily with no results, but these are much more effective. I consume plenty of fibre, focusing solely on healthy vegetable foods.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.5
- All Researches
9
We aimed to find out if probiotic supplements like lactobacillus acidophilus could help counteract the negative effects of iron fortification, which has been linked to increased diarrhea and food poisoning among children.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
Read More
9
Probiotics reduce Salmonella colonization
We looked at how an avian-specific probiotic could help reduce food poisoning risks linked to Salmonella Enteritidis in poultry. Our study used chicks that received a special probiotic treatment and compared them to a control group.
The results showed a marked decrease in Salmonella Enteritidis colonization in the treated chicks over several days, especially at days 3, 7, and beyond. However, body weight gains appeared similar between both groups.
Overall, our findings suggest that using Lactobacillus acidophilus as part of the treatment may effectively lower Salmonella risks in broilers.
The results showed a marked decrease in Salmonella Enteritidis colonization in the treated chicks over several days, especially at days 3, 7, and beyond. However, body weight gains appeared similar between both groups.
Overall, our findings suggest that using Lactobacillus acidophilus as part of the treatment may effectively lower Salmonella risks in broilers.
Read More
9
Lacticaseibacillus rhamnosus shows promise
We explored the potential of Lacticaseibacillus rhamnosus GG as a probiotic treatment against avian pathogenic E. coli (APEC) in chickens. Our study showed that this probiotic significantly reduced APEC colonization in the chickens' cecum and improved the balance of gut microbiota over a 24-hour period.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
Read More
9
Lactococcus lactis enhances toxin immunity
We explored the potential of Lactococcus lactis (L. lactis) as an oral vaccine to fight against harmful Shiga toxins produced by bacteria such as E. coli O157:H7 and Shigella dysenteriae. In our study with BALB/c mice, those immunized with a specific strain of L. lactis showed impressive protection, with survival rates of 84% and 100% when exposed to these toxins. The immunization resulted in significant antibody production and minimized organ damage, demonstrating L. lactis's promising role in developing an effective oral vaccine against these toxins.
Read More
9
We investigated how a specific strain of Lactococcus lactis can help prevent food poisoning caused by a common pathogen found in raw milk and cheese. Our results showed a significant decrease in pathogen levels—by around 3 log CFU/mL—within just six hours when this strain was present.
Even more promising, it reduced the production of staphylococcal enterotoxin A (SEA) by 79%. In cheeses made with Lactococcus lactis, SEA was never detected, while it was found in higher levels in cheeses made without this protective strain. This study clearly shows Lactococcus lactis's potential in enhancing food safety through biopreservation.
Even more promising, it reduced the production of staphylococcal enterotoxin A (SEA) by 79%. In cheeses made with Lactococcus lactis, SEA was never detected, while it was found in higher levels in cheeses made without this protective strain. This study clearly shows Lactococcus lactis's potential in enhancing food safety through biopreservation.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Convenient probiotic
8 people found this helpful
Working probiotic! A convenient product with positive results after two months. It has helped my whole family cope during these challenging times when food quality is often poor. I am ordering more and recommend it to friends!
Read More
7
Restores microflora
5 people found this helpful
Works well and restores intestinal microflora effectively. I take it in the morning on an empty stomach or at night with water. It aids digestion and is necessary for inflammation of the pancreas. A very good drug that I recommend.
Read More
7.5
Effective for intestines
1 people found this helpful
An effective product! These probiotics perfectly help with my intestines, which struggle to function properly. I previously took six capsules of Lineks daily with no results, but these are much more effective. I consume plenty of fibre, focusing solely on healthy vegetable foods.
Read More
8
Important for health
The best probiotic capsules available. I'm using these to address my food allergy issues, along with cat's claw. The microbiome is vital for our health, as 80% of our immune system resides in the gut, underscoring the significant power of probiotics.
Read More
5
Restores intestinal microflora
"Acidophilus Plus" capsules are highly recommended as a source of probiotic microorganisms, helping restore intestinal microflora. They utilize double encapsulation technology for viable bacteria as they pass through the gastrointestinal tract and are suitable for those with lactose intolerance.
Read More
Frequently Asked Questions
9
Convenient probiotic
8 people found this helpful
Working probiotic! A convenient product with positive results after two months. It has helped my whole family cope during these challenging times when food quality is often poor. I am ordering more and recommend it to friends!
7
Restores microflora
5 people found this helpful
Works well and restores intestinal microflora effectively. I take it in the morning on an empty stomach or at night with water. It aids digestion and is necessary for inflammation of the pancreas. A very good drug that I recommend.
7.5
Effective for intestines
1 people found this helpful
An effective product! These probiotics perfectly help with my intestines, which struggle to function properly. I previously took six capsules of Lineks daily with no results, but these are much more effective. I consume plenty of fibre, focusing solely on healthy vegetable foods.
8
Important for health
The best probiotic capsules available. I'm using these to address my food allergy issues, along with cat's claw. The microbiome is vital for our health, as 80% of our immune system resides in the gut, underscoring the significant power of probiotics.
9
We aimed to find out if probiotic supplements like lactobacillus acidophilus could help counteract the negative effects of iron fortification, which has been linked to increased diarrhea and food poisoning among children.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
7
We explored whether Lactobacillus acidophilus, in both live and heat-killed forms, could protect against Salmonella-induced food poisoning. For two weeks, Sprague-Dawley rats received oral doses of L. acidophilus before being exposed to Salmonella.
The rats treated with heat-killed bacteria showed only a moderate rise in body temperature and maintained normal feeding and drinking habits. Although the number of Salmonella in feces was similar in both groups, heat-killed L. acidophilus significantly reduced inflammatory markers compared to the control group.
While it appears L. acidophilus may aid in managing Salmonella infections, it’s important to note that its overall impact may be limited.
The rats treated with heat-killed bacteria showed only a moderate rise in body temperature and maintained normal feeding and drinking habits. Although the number of Salmonella in feces was similar in both groups, heat-killed L. acidophilus significantly reduced inflammatory markers compared to the control group.
While it appears L. acidophilus may aid in managing Salmonella infections, it’s important to note that its overall impact may be limited.
9
Lactococcus lactis enhances toxin immunity
We explored the potential of Lactococcus lactis (L. lactis) as an oral vaccine to fight against harmful Shiga toxins produced by bacteria such as E. coli O157:H7 and Shigella dysenteriae. In our study with BALB/c mice, those immunized with a specific strain of L. lactis showed impressive protection, with survival rates of 84% and 100% when exposed to these toxins. The immunization resulted in significant antibody production and minimized organ damage, demonstrating L. lactis's promising role in developing an effective oral vaccine against these toxins.
References
- Lin F, Wu H, Zeng M, Yu G, Dong S, et al. Probiotic/prebiotic correction for adverse effects of iron fortification on intestinal resistance to Salmonella infection in weaning mice. Food Funct. 2018;9:1070. 10.1039/c7fo00990a
- Kim MS, Yoon YS, Seo JG, Lee HG, Chung MJ, et al. A study on the prevention of salmonella infection by using the aggregation characteristics of lactic Acid bacteria. Toxicol Res. 2013;29:129. 10.5487/TR.2013.29.2.129
- Tellez G, Petrone VM, Escorcia M, Morishita TY, Cobb CW, et al. Evaluation of avian-specific probiotic and Salmonella enteritidis-, Salmonella typhimurium-, and Salmonella heidelberg-specific antibodies on cecal colonization and organ invasion of Salmonella enteritidis in broilers. J Food Prot. 2001;64:287.
- Kathayat D, Closs G, Helmy YA, Deblais L, Srivastava V, et al. In Vitro and In Vivo Evaluation of Lacticaseibacillus rhamnosus GG and Bifidobacterium lactis Bb12 Against Avian Pathogenic Escherichia coli and Identification of Novel Probiotic-Derived Bioactive Peptides. Probiotics Antimicrob Proteins. 2022;14:1012. 10.1007/s12602-021-09840-1
- Aljasir SF, D'Amico DJ. The effect of protective cultures on Staphylococcus aureus growth and enterotoxin production. Food Microbiol. 2020;91:103541. 10.1016/j.fm.2020.103541
- Sreerohini S, Balakrishna K, Parida M. Oral immunization of mice with Lactococcus lactis expressing Shiga toxin truncate confers enhanced protection against Shiga toxins of Escherichia coli O157:H7 and Shigella dysenteriae. APMIS. 2019;127:671. 10.1111/apm.12983
- Smialek M, Burchardt S, Koncicki A. The influence of probiotic supplementation in broiler chickens on population and carcass contamination with Campylobacter spp. - Field study. Res Vet Sci. 2018;118:312. 10.1016/j.rvsc.2018.03.009
- Tetili F, Bendali F, Perrier J, Sadoun D. Anti-Staphylococcal Enterotoxinogenesis of in Algerian Raw Milk Cheese. Food Technol Biotechnol. 2017;55:511. 10.17113/ftb.55.04.17.5105
- Nouaille S, Rault L, Jeanson S, Loubière P, Le Loir Y, et al. Contribution of Lactococcus lactis reducing properties to the downregulation of a major virulence regulator in Staphylococcus aureus, the agr system. Appl Environ Microbiol. 2014;80:7028. 10.1128/AEM.02287-14
- Asensi GF, de Sales NF, Dutra FF, Feijó DF, Bozza MT, et al. Oral immunization with Lactococcus lactis secreting attenuated recombinant staphylococcal enterotoxin B induces a protective immune response in a murine model. Microb Cell Fact. 2013;12:32. 10.1186/1475-2859-12-32
